Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
USERS' SCORE
Good
Based on 9 Reviews
8.1
Supplement Facts
Serving Size: 2 Enteric Coated Softgels
Amount Per Serving
%DV
Calories
25
Total Fat
2.5 g
4%†
Cholesterol
<5 mg
2%†
Pure+™ Wild Fish Oil ConcentrateYielding: EPA (eicosapentaenoic acid)DHA (docosahexaenoic acid)
2,000 mg700 mg500 mg
******
Polyphen-Oil™ Olive extract (fruit and leaf)[providing 19.5 mg polyphenols, 5.2 mg hydroxytyrosol/tyrosol, 4.4 mg verbascoside/oleuropein]
300 mg
**
Sesame seed lignan extract
10 mg
**
Top Medical Research Studies
9
Omega-3s' mixed effects on heart health
We examined the impact of omega-3 fatty acids, often found in fish oil, on heart attack risks, particularly in patients with high triglyceride levels. The studies indicate that while omega-3s can effectively lower triglycerides and reduce certain cardiovascular disease outcomes, including fatal heart attacks, their overall benefit remains debated. Despite extensive research demonstrating some positive outcomes, many experts still question the magnitude of their effects on heart attack prevention. Improved guidance on omega-3 supplementation is still evolving as new evidence emerges.
Read More
8
Omega-3 reduces heart attack risk
We explored the impact of omega-3 fatty acids on heart attack risk, focusing on African Americans. In a study analyzing data from the VITAL trial, we matched African American participants with non-Hispanic White individuals to simulate a randomized controlled trial.
Surprisingly, our findings indicated that omega-3 supplementation significantly decreased heart attack risk in African Americans but showed no benefit for non-Hispanic Whites. This highlights the importance of addressing racial differences in how individuals respond to omega-3 fish oil, urging further research in this area.
Surprisingly, our findings indicated that omega-3 supplementation significantly decreased heart attack risk in African Americans but showed no benefit for non-Hispanic Whites. This highlights the importance of addressing racial differences in how individuals respond to omega-3 fish oil, urging further research in this area.
Read More
8
We delved into how different types of fatty acids influence the risk of coronary heart disease (CHD) using data from a large study of over 89,000 adults.
Our findings revealed that omega-3 fatty acids seemed to lower the risk of CHD, standing out among other fatty acids. Interestingly, saturated and monounsaturated fats did show a positive link to CHD, but this was largely connected to their effect on triglyceride levels.
Overall, omega-3 fatty acids might offer a protective benefit against heart disease.
Our findings revealed that omega-3 fatty acids seemed to lower the risk of CHD, standing out among other fatty acids. Interestingly, saturated and monounsaturated fats did show a positive link to CHD, but this was largely connected to their effect on triglyceride levels.
Overall, omega-3 fatty acids might offer a protective benefit against heart disease.
Read More
Most Useful Reviews
9
Supports heart health
1 people found this helpful
This excellent supplement has greatly supported my heart health and improved my cognitive function while reducing inflammation. The results have been remarkable, and I plan to continue using it. I've noticed better heart function and an overall sense of alertness, along with improved focus after a few weeks of use, as well as a reduction in mild fatigue post-exercise.
Read More
9
Supports overall health
This omega is of exceptional quality. The ingredients truly shine. It benefits my entire body, supports heart function, restores cholesterol levels, alleviates inflammation, and improves joint health, hair, skin, and nails. It has a neutral taste and is easy to ingest, contributing significantly to cognitive health. I wholeheartedly recommend it.
Read More
7.5
Reduced palpitations
1 people found this helpful
My palpitations seem to have decreased significantly. Indefinite complaints and headaches have also diminished. While this might not be the sole reason, fish is expensive, and the hassle of cooking and cleaning is tedious, so I find supplements much more convenient, and that's why I continue taking them.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
- All Researches
9
Omega-3s' mixed effects on heart health
We examined the impact of omega-3 fatty acids, often found in fish oil, on heart attack risks, particularly in patients with high triglyceride levels. The studies indicate that while omega-3s can effectively lower triglycerides and reduce certain cardiovascular disease outcomes, including fatal heart attacks, their overall benefit remains debated. Despite extensive research demonstrating some positive outcomes, many experts still question the magnitude of their effects on heart attack prevention. Improved guidance on omega-3 supplementation is still evolving as new evidence emerges.
Read More
9
We explored whether icosapent ethyl (IPE), a refined omega-3 fatty acid, could lower heart attack risk among cigarette smokers. In the REDUCE-IT trial, over 8,000 statin-treated patients were randomly assigned to receive either IPE or a placebo for nearly five years.
Our findings showed that IPE significantly reduced cardiovascular events by 25%, especially for current and former smokers. Participants using IPE experienced heart attack rates similar to non-smokers, suggesting that IPE may help lessen cardiovascular risks associated with smoking.
Our findings showed that IPE significantly reduced cardiovascular events by 25%, especially for current and former smokers. Participants using IPE experienced heart attack rates similar to non-smokers, suggesting that IPE may help lessen cardiovascular risks associated with smoking.
Read More
8
Omega-3 reduces heart attack risk
We investigated whether icosapent ethyl is beneficial in reducing heart attack rates among patients with well-managed low-density lipoprotein cholesterol (LDL-C).
Analyzing data from the REDUCE-IT trial, we found that this treatment significantly lowered cardiovascular complications in statin-treated patients, regardless of their baseline LDL-C levels.
Specifically, it proved effective for those with optimal LDL-C control, showing that even patients with very low cholesterol can benefit from this omega-3 treatment in preventing serious heart events.
Analyzing data from the REDUCE-IT trial, we found that this treatment significantly lowered cardiovascular complications in statin-treated patients, regardless of their baseline LDL-C levels.
Specifically, it proved effective for those with optimal LDL-C control, showing that even patients with very low cholesterol can benefit from this omega-3 treatment in preventing serious heart events.
Read More
8
Omega-3 reduces heart attack risk
We explored the impact of omega-3 fatty acids on heart attack risk, focusing on African Americans. In a study analyzing data from the VITAL trial, we matched African American participants with non-Hispanic White individuals to simulate a randomized controlled trial.
Surprisingly, our findings indicated that omega-3 supplementation significantly decreased heart attack risk in African Americans but showed no benefit for non-Hispanic Whites. This highlights the importance of addressing racial differences in how individuals respond to omega-3 fish oil, urging further research in this area.
Surprisingly, our findings indicated that omega-3 supplementation significantly decreased heart attack risk in African Americans but showed no benefit for non-Hispanic Whites. This highlights the importance of addressing racial differences in how individuals respond to omega-3 fish oil, urging further research in this area.
Read More
8
Omega-3 improves heart attack outcomes
We observed that icosapent ethyl, a type of omega-3 fish oil, plays a significant role in reducing heart attack risk among patients with atherosclerotic cardiovascular disease (ASCVD). In a study involving almost 5,800 participants, those taking icosapent ethyl experienced lower rates of major adverse cardiovascular events (MACE) compared to those on placebo.
The treatment showed effectiveness across all levels of cardiovascular risk, particularly benefiting those at higher risk. Overall, this suggests that incorporating icosapent ethyl could be an important option for managing heart attack risks.
The treatment showed effectiveness across all levels of cardiovascular risk, particularly benefiting those at higher risk. Overall, this suggests that incorporating icosapent ethyl could be an important option for managing heart attack risks.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports heart health
1 people found this helpful
This excellent supplement has greatly supported my heart health and improved my cognitive function while reducing inflammation. The results have been remarkable, and I plan to continue using it. I've noticed better heart function and an overall sense of alertness, along with improved focus after a few weeks of use, as well as a reduction in mild fatigue post-exercise.
Read More
9
Supports overall health
This omega is of exceptional quality. The ingredients truly shine. It benefits my entire body, supports heart function, restores cholesterol levels, alleviates inflammation, and improves joint health, hair, skin, and nails. It has a neutral taste and is easy to ingest, contributing significantly to cognitive health. I wholeheartedly recommend it.
Read More
7.5
Reduced palpitations
1 people found this helpful
My palpitations seem to have decreased significantly. Indefinite complaints and headaches have also diminished. While this might not be the sole reason, fish is expensive, and the hassle of cooking and cleaning is tedious, so I find supplements much more convenient, and that's why I continue taking them.
Read More
9
Supports heart health
This product is amazing! It promotes cardiovascular and cognitive health, effectively maintaining triglyceride, HDL, and LDL cholesterol levels. It includes heart-healthy Mediterranean sesame and olive extracts and is made with IFOS™ certified anchovies, sustainably sourced from the South Pacific coast of Chile.
Read More
7.5
Complex supplement
This omega is sourced from wild fish, which is significant, and it carries certificates that guarantee its purity. It also contains polyphenols from olive leaves and fruits, which support the cardiovascular and circulatory systems alongside omega-3. Together, they form a valuable complex for heart and blood vessel health. Given the price per share, it's not much more than standard options.
Read More
Frequently Asked Questions
9
Supports heart health
1 people found this helpful
This excellent supplement has greatly supported my heart health and improved my cognitive function while reducing inflammation. The results have been remarkable, and I plan to continue using it. I've noticed better heart function and an overall sense of alertness, along with improved focus after a few weeks of use, as well as a reduction in mild fatigue post-exercise.
6
Heart health improvement
Omega-3 for adults has good quality. My family and I take omega for three months and then take a break. It positively impacts heart function and improves our well-being. My hair has become thicker and shinier. I recommend purchasing it.
7.5
Reduced palpitations
1 people found this helpful
My palpitations seem to have decreased significantly. Indefinite complaints and headaches have also diminished. While this might not be the sole reason, fish is expensive, and the hassle of cooking and cleaning is tedious, so I find supplements much more convenient, and that's why I continue taking them.
9
Supports overall health
This omega is of exceptional quality. The ingredients truly shine. It benefits my entire body, supports heart function, restores cholesterol levels, alleviates inflammation, and improves joint health, hair, skin, and nails. It has a neutral taste and is easy to ingest, contributing significantly to cognitive health. I wholeheartedly recommend it.
7.5
Complex supplement
This omega is sourced from wild fish, which is significant, and it carries certificates that guarantee its purity. It also contains polyphenols from olive leaves and fruits, which support the cardiovascular and circulatory systems alongside omega-3. Together, they form a valuable complex for heart and blood vessel health. Given the price per share, it's not much more than standard options.
8
Omega-3 reduces heart attack risk
We investigated whether icosapent ethyl is beneficial in reducing heart attack rates among patients with well-managed low-density lipoprotein cholesterol (LDL-C).
Analyzing data from the REDUCE-IT trial, we found that this treatment significantly lowered cardiovascular complications in statin-treated patients, regardless of their baseline LDL-C levels.
Specifically, it proved effective for those with optimal LDL-C control, showing that even patients with very low cholesterol can benefit from this omega-3 treatment in preventing serious heart events.
Analyzing data from the REDUCE-IT trial, we found that this treatment significantly lowered cardiovascular complications in statin-treated patients, regardless of their baseline LDL-C levels.
Specifically, it proved effective for those with optimal LDL-C control, showing that even patients with very low cholesterol can benefit from this omega-3 treatment in preventing serious heart events.
8
Omega-3 reduces heart attack risk
We explored the impact of omega-3 fatty acids on heart attack risk, focusing on African Americans. In a study analyzing data from the VITAL trial, we matched African American participants with non-Hispanic White individuals to simulate a randomized controlled trial.
Surprisingly, our findings indicated that omega-3 supplementation significantly decreased heart attack risk in African Americans but showed no benefit for non-Hispanic Whites. This highlights the importance of addressing racial differences in how individuals respond to omega-3 fish oil, urging further research in this area.
Surprisingly, our findings indicated that omega-3 supplementation significantly decreased heart attack risk in African Americans but showed no benefit for non-Hispanic Whites. This highlights the importance of addressing racial differences in how individuals respond to omega-3 fish oil, urging further research in this area.
9
Omega-3s' mixed effects on heart health
We examined the impact of omega-3 fatty acids, often found in fish oil, on heart attack risks, particularly in patients with high triglyceride levels. The studies indicate that while omega-3s can effectively lower triglycerides and reduce certain cardiovascular disease outcomes, including fatal heart attacks, their overall benefit remains debated. Despite extensive research demonstrating some positive outcomes, many experts still question the magnitude of their effects on heart attack prevention. Improved guidance on omega-3 supplementation is still evolving as new evidence emerges.
We are investigating the impact of highly purified eicosapentaenoic acid (EPA) combined with statin treatment on preventing heart attacks and other cardiovascular issues. The RESPECT-EPA study involves a randomized trial where participants with low EPA/arachidonic acid (AA) ratios are assigned to either EPA or a control.
Our primary goal is to determine if this combination can reduce occurrences of heart attacks and other major cardiovascular events. The study will also evaluate if the EPA/AA ratio can serve as a reliable predictor for future heart issues.
Results from this ongoing study will enhance our understanding of EPA’s effectiveness in secondary prevention for those at risk.
Our primary goal is to determine if this combination can reduce occurrences of heart attacks and other major cardiovascular events. The study will also evaluate if the EPA/AA ratio can serve as a reliable predictor for future heart issues.
Results from this ongoing study will enhance our understanding of EPA’s effectiveness in secondary prevention for those at risk.
9
We explored whether icosapent ethyl (IPE), a refined omega-3 fatty acid, could lower heart attack risk among cigarette smokers. In the REDUCE-IT trial, over 8,000 statin-treated patients were randomly assigned to receive either IPE or a placebo for nearly five years.
Our findings showed that IPE significantly reduced cardiovascular events by 25%, especially for current and former smokers. Participants using IPE experienced heart attack rates similar to non-smokers, suggesting that IPE may help lessen cardiovascular risks associated with smoking.
Our findings showed that IPE significantly reduced cardiovascular events by 25%, especially for current and former smokers. Participants using IPE experienced heart attack rates similar to non-smokers, suggesting that IPE may help lessen cardiovascular risks associated with smoking.
8
We explored the effects of omega-3 fatty acids on preventing heart attacks through the VITamin D and OmegA-3 TriaL (VITAL), which involved nearly 26,000 adults. Participants received either omega-3 fish oil or an olive oil placebo for over five years.
Although the overall findings didn't show a significant reduction in major cardiovascular events, omega-3 supplementation did lower the risk of heart attacks and recurrent hospitalizations for heart failure. Interestingly, African Americans benefited the most from the treatment, showing substantial improvements in these areas.
More research is needed to identify which individuals might gain the most from omega-3 fish oil treatment.
Although the overall findings didn't show a significant reduction in major cardiovascular events, omega-3 supplementation did lower the risk of heart attacks and recurrent hospitalizations for heart failure. Interestingly, African Americans benefited the most from the treatment, showing substantial improvements in these areas.
More research is needed to identify which individuals might gain the most from omega-3 fish oil treatment.
References
- Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. 10.1161/JAHA.124.038656
- Sun S, Hara A, Johnstone L, Hallmark B, Watkins JC, et al. Optimal Pair Matching Combined with Machine Learning Predicts a Significant Reduction in Myocardial Infarction Risk in African Americans Following Omega-3 Fatty Acid Supplementation. Nutrients. 2024;16. 10.3390/nu16172933
- Ahmadi M, Askari VR, Shahri B, Mousavi Noghab SM, Jarahi L, et al. Omega-3 fatty acids effectively mitigate high-sensitivity C-reactive protein (hs-CRP) biomarker of inflammation in acute myocardial infarction patients: a randomized, double-blind, placebo-controlled clinical trial. Naunyn Schmiedebergs Arch Pharmacol. 2025;398:881. 10.1007/s00210-024-03330-1
- Burger PM, Bhatt DL, Dorresteijn JAN, Koudstaal S, Mosterd A, et al. Effects of icosapent ethyl according to baseline residual risk in patients with atherosclerotic cardiovascular disease: results from REDUCE-IT. Eur Heart J Cardiovasc Pharmacother. 2024;10:488. 10.1093/ehjcvp/pvae030
- Bernhard B, Heydari B, Abdullah S, Francis SA, Lumish H, et al. Effect of six month's treatment with omega-3 acid ethyl esters on long-term outcomes after acute myocardial infarction: The OMEGA-REMODEL randomized clinical trial. Int J Cardiol. 2024;399:131698. 10.1016/j.ijcard.2023.131698
- Irfan A, Haider SH, Nasir A, Larik MO, Naz T. Assessing the Efficacy of Omega-3 Fatty Acids + Statins vs. Statins Only on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of 40,991 Patients. Curr Probl Cardiol. 2024;49:102245. 10.1016/j.cpcardiol.2023.102245
- Ogata S, Manson JE, Kang JH, Buring JE, Lee IM, et al. Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease: A Novel Analysis of the VITAL Trial Using Win Ratio and Hierarchical Composite Outcomes. Nutrients. 2023;15. 10.3390/nu15194235
- Jin D, Trichia E, Islam N, Lewington S, Lacey B. Associations of circulating fatty acids with incident coronary heart disease: a prospective study of 89,242 individuals in UK Biobank. BMC Cardiovasc Disord. 2023;23:365. 10.1186/s12872-023-03394-6
- Lyytinen AT, Yesmean M, Manninen S, Lankinen M, Bhalke M, et al. Fatty fish consumption reduces lipophilic index in erythrocyte membranes and serum phospholipids. Nutr Metab Cardiovasc Dis. 2023;33:1453. 10.1016/j.numecd.2023.04.011
- Chiusolo S, Bork CS, Gentile F, Lundbye-Christensen S, Harris WS, et al. Adipose tissue n-3/n-6 fatty acids ratios versus n-3 fatty acids fractions as predictors of myocardial infarction. Am Heart J. 2023;262:38. 10.1016/j.ahj.2023.03.019
- Kobara M, Shiraishi T, Noda K, Toba H, Nakata T. Eicosapentaenoic Acid Preserves Mitochondrial Quality and Attenuates Cardiac Remodeling After Myocardial Infarction in Rats. J Cardiovasc Transl Res. 2023;16:816. 10.1007/s12265-023-10363-z
- Rodriguez D, Lavie CJ, Elagizi A, Milani RV. Update on Omega-3 Polyunsaturated Fatty Acids on Cardiovascular Health. Nutrients. 2022;14. 10.3390/nu14235146
- Bassuk SS, Manson JE. Marine omega-3 fatty acid supplementation and prevention of cardiovascular disease: update on the randomized trial evidence. Cardiovasc Res. 2023;119:1297. 10.1093/cvr/cvac172
- Nishizaki Y, Miyauchi K, Iwata H, Inoue T, Hirayama A, et al. Study protocol and baseline characteristics of Randomized trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy-Statin and Eicosapentaenoic Acid: RESPECT-EPA, the combination of a randomized control trial and an observational biomarker study. Am Heart J. 2023;257:1. 10.1016/j.ahj.2022.11.008
- Miller M, Bhatt DL, Steg PG, Brinton EA, Jacobson TA, et al. Potential effects of icosapent ethyl on cardiovascular outcomes in cigarette smokers: REDUCE-IT smoking. Eur Heart J Cardiovasc Pharmacother. 2023;9:129. 10.1093/ehjcvp/pvac045
- Yokoyama Y, Kuno T, Morita SX, Slipczuk L, Takagi H, et al. Eicosapentaenoic Acid for Cardiovascular Events Reduction- Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. J Cardiol. 2022;80:416. 10.1016/j.jjcc.2022.07.008
